Bolshaya Ussurka River (Russian: Большая Уссурка, literally: Great Ussuri) is a river on Russian Far East in Primorsky Krai, a right tributary of Ussuri River.
The area of the Bolshaya Ussurka River drainage basin is approximately 29,600 km². It is 440 km in length.
The major tributaries of Bolshaya Ussurka River are Malinovka, Marevka, Naumovka and Armu Rivers.